in Australia and New Zealand
Research · peer-reviewed & institutional
Research and university publications behind the Alpro system, independent university studies and institutional reports, open to read in full and quoted exactly as published.
Gutachten · Scientific Data
Independent laboratory reports (Gutachten) for Alpro products available in Australia & New Zealand, as published in the Alpro Medical Programm 2026–2027 catalogue.
Source: Alpro Medical Programm 2026–2027, pp. 70–71 — Gutachten / Scientific Data. Wording as printed. Not an Australian therapeutic claim — verify against current Product Information before any external or clinical use.
HygCen Germany GmbH
Dr. Brill + Partner GmbH
Gesamtgutachten: Prof. Dr. rer. nat. Dr. med. habil. Friedrich von Rheinbaben
HygCen Germany GmbH
Dr. Brill + Partner GmbH
Gesamtgutachten: Prof. Dr. rer. nat. Dr. med. habil. Friedrich von Rheinbaben
HygCen Germany GmbH
Dr. Brill + Partner GmbH
Technische Mikrobiologie Dr. Jutta Höffler GmbH
Prof. Dr. R. Schubert
Catalogue: BIB forte eco
Dr. Brill + Partner GmbH
HygCen Germany GmbH
Mikrolab GmbH
Dr. Brill + Partner GmbH
SMP GmbH
HygCen Germany GmbH
Catalogue: PlastiSept eco + PlastiSept eco Wipes
HygCen Germany GmbH
Dr. Brill + Partner GmbH
Iki – Institut für Krankenhaushygiene und Infektionskontrolle GmbH
HygCen Germany GmbH
Dr. Brill + Partner GmbH
Catalogue extract for the AU/NZ range only. Products without a Gutachten entry on pp. 70–71 are omitted. Full scientific-data summary available to dental professionals on request.
A. J. Smith, S. McHugh, I. Aitken and J. Hood. Evaluation of the efficacy of Alpron disinfectant for dental unit water lines. Br Dent J 2002; 193: 593–596.
Glasgow Dental Hospital · British Dental Journal
Alpron 1% disrupted biofilm; 37 °C counts held < 10 CFU/mL; 4 of 6 units stayed low for 13 weeks on one course.
Alpron-company grant.
M. Özcan, Y. Kulak and E. Kazazoğlu. The effect of disinfectant agents in eliminating the contamination of dental unit water. J Oral Rehabil. 2003;30:290-294.
Marmara University, Turkey · J Oral Rehabilitation · independent
Alpron daily reduced DUWL contamination to 0 CFU/mL by week 2; no Gram-negative pathogens.
Julie Lizon, Arnaud Florentin, Jean-Marc Martrette, Alexandre Rivier, Celine Clement, Christian Rabaud. Microbial control of dental unit water: Feedback on different disinfection methods experience. Am J Infect Control. 2015. doi: 10.1016/j.ajic.2015.08.029.
Nancy University Hospital, France · Am J Infection Control · independent
Continuous Alpron + Bilpron held ~1–2 CFU/mL and 0% non-compliance for 18 months with no pathogens, where intermittent competitor chemistry failed.
Leeds Teaching Hospitals NHS Trust · clinical SOP
Standard practice: BRS-Forte to remove biofilm + Alpron 1% continuous to maintain; quarterly monitoring; action threshold < 100 CFU/mL (HTM 01-05).
Academic Centre for Dentistry Amsterdam · in-house report
Across 164 units, Bilpron (Weekend System) + BRS outperformed peroxide, urea-peroxide and Alpron; Alpron reached <100 CFU/mL in 11/12 units after 2 weeks (post-BRS). Judged one of the best DUWL systems — when the protocol is followed.
Institutional report (not peer-reviewed); depends on protocol compliance + bottle hygiene.
Kielbassa AM, Attin T, Kümmerer K, Hellwig E. Quecksilberfreisetzung aus abgeschiedenem Amalgam nach Anwendung unterschiedlicher Desinfektionsmittel [Mercury release from separated amalgam after the use of different disinfectants]. Schweiz Monatsschr Zahnmed. 1995;105(12):1534-8. German. PMID: 8553038.
Albert-Ludwigs-Universität Freiburg · Schweiz Monatsschr Zahnmed. 1995;105(12):1534-8
pubmed.ncbi.nlm.nih.gov/8553038
In suction units with amalgam separators, AlproJet D disinfection produced mercury release comparable to a water-rinse control; disinfectants with oxidising agents significantly increased mercury release into wastewater.
Article in German.
Büchter A, Kruse-Loesler B. Development of a validated process for manual preparation of dental transmission instruments. Clin Oral Investig. 2011 Oct;15(5):605-8. doi: 10.1007/s00784-010-0425-7. Epub 2010 May 19. PMID: 20490580.
Clin Oral Investig. 2011 Oct;15(5):605-8 · doi: 10.1007/s00784-010-0425-7
pubmed.ncbi.nlm.nih.gov/20490580
A validated manual preparation process for dental turbines, handpieces and contra-angles using WL-clean (with WL-Cid and WL-Dry) met the protein-residue acceptance criteria of the validation guideline (DIN EN 15883-1).
Zemouri C, de Soet JJ, Volgenant CMC, Crielaard W, Laheij AMGA. Heterogeneity in the efficacy of dental chemical disinfectants on water-derived biofilms in vitro. Biofouling. 2020 May;36(5):587-596. doi: 10.1080/08927014.2020.1782894. Epub 2020 Jun 25. PMID: 32580580.
Academic Centre for Dentistry Amsterdam · Biofouling. 2020 May;36(5):587-596 · doi: 10.1080/08927014.2020.1782894
pubmed.ncbi.nlm.nih.gov/32580580
In a static water-derived biofilm model, disinfectant concentration and composition influenced culturable bacteria; a shock dose followed by a low maintenance dose suppressed viable bacteria most. Alpron/Bilpron had a substantial effect, while Citrisil and ICX consistently failed to control biofilms.
Baudet A, Lizon J, Martrette JM, Camelot F, Florentin A, Clément C. Efficacy of BRS® and Alpron®/Bilpron® Disinfectants for Dental Unit Waterlines: A Six-Year Study. Int J Environ Res Public Health. 2020 Apr 12;17(8):2634. doi: 10.3390/ijerph17082634. PMID: 32290533; PMCID: PMC7215904.
University of Lorraine / University Hospital Nancy · Int J Environ Res Public Health. 2020 Apr 12;17(8):2634 · doi: 10.3390/ijerph17082634
pubmed.ncbi.nlm.nih.gov/32290533
Over six years, 68 dental units shock-treated with BRS then maintained with Alpron (working days) and Bilpron (idle periods) yielded 99.8% of 628 samples compliant with extended microbiological levels; Legionella sp. and Pseudomonas aeruginosa were never detected.
Figures are as published in each study — verify before any external use.
Beyond the field studies, the Alpro chemistry is independently tested to recognised European standards (EN / RKI / DVV / VAH). The summary below is manufacturer / EU test data — not an Australian therapeutic claim. Confirm the on-label organisms and contact times in each product’s current Product Information.
| Product | Spectrum tested | To European standards | Contact time | AU status |
|---|---|---|---|---|
| AlpronWater management | Bactericidal — disinfection regime, 10% in 12 h (Klebsiella pneumoniae, Pseudomonas aeruginosa) · Conservation of procedural water — 1% for 28 days (Burkholderia cepacia, Enterococcus faecium, Legionella pneumophila, Ps. aeruginosa) | EN 13623 · Ph. Eur. 5.1.3 | — | ARTG 226413 |
| BilpronWater management | Bactericidal — ready-to-use solution, 2 hours (Klebsiella pneumoniae, Pseudomonas aeruginosa) · Conservation of procedural water — 28 days (Burkholderia cepacia, Enterococcus faecium, Legionella pneumophila, Ps. aeruginosa) | EN 13623 · Ph. Eur. 5.1.3 | — | ARTG 226413 |
| BRS Kit — Biofilm Removing SetWater management | Bacterial hazard in dental practice — how clean is the water in your dental unit? | Interview · Prof. Laurence Walsh | — | ARTG 226414 |
| BIB forteInstruments | Bactericidal (incl. MRSA) · Virucidal (enveloped viruses) | EN 13727 · EN 14561 · RKI / DVV | 10 min bactericidal · 5 min ultrasonic · 10 min virucidal (enveloped viruses) | ARTG 167778 |
| BC-San 100Water management | VIRUCIDAL · SPORICIDAL · MICROBICIDAL | EN 16777 · EN 17126 · microbiologically tested efficacy | At least 6 hours (overnight) | — |
| PlastiSept ecoSurfaces | Bactericidal (incl. MRSA) · Yeasticidal · Virucidal (enveloped viruses) | EN 13727 · EN 16615 · VAH · EN 13624 · EN 14476 · EN 16777 | Bactericidal/MRSA 5 min · Yeasticidal 1 min · Virucidal 5 min | ARTG 164389 |
| PlastiSept eco Jumbo WipeSurfaces | Bactericidal · Yeasticidal · Tuberculocidal · Virucidal (enveloped viruses) | EN 13727 · EN 16615 · EN 13624 · EN 14348 · EN 14476 · EN 16777 · VAH | — | ARTG 293206 |
Manufacturer / EU test data, per current Product Information — verify before any external or clinical use. The full scientific-data summary (European testing, with test institutes and dates) is available to dental professionals on request.
Compliance
Findings are only useful at audit if they are organised and citable. The Compliance page maps the source-verified library to AS 5369 audit readiness, zone by zone — support, not certification.
1% additive — 10 mL Alpron to 990 mL water; one 1 L bottle makes 100 bottles of procedural water. Undiluted for a periodic decontamination.
Source: Alpron — Product Information (REF 3183)At least 12 hours (over a closure), and it can stay up to 3 months. Flush until clear on restart; don’t reuse.
Source: Bilpron — Product Information (REF 3181)A widely cited international benchmark is the American Dental Association's ≤200 CFU/mL; check with a Biotester, and if counts rise, shock the lines with the BRS and re-test. Confirm the target that applies to your practice with your compliance adviser.
Source: American Dental Association (USA) ≤200 CFU/mL benchmark · Biotester guideBRS PreCleaner is corrosive (gloves + eye protection) and BRS Remover 3 is an eye irritant. Bilpron and PlastiSept eco are not hazard-signalled.
Source: Safety Data SheetsNo — it isn’t validated and can void the equipment manufacturer’s warranty. Contact support to confirm any compatibility question.
Source: Alpro — compatibility & warranty policyAutomated product guidance only—not medical advice, a treatment recommendation or compliance certification. Manufacturer instructions take priority. If an answer is unclear or conflicts with a product document, ask Biodegree support before use. Not for emergencies; seek urgent professional help.
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